Welcome Packet Information

We appreciate your participation and look forward to working with you. This study is being conducted through Auburn University by Dr. Jennifer Robinson.  This document will help you understand all of the different components of the study. It is important that you read this document carefully. We also provide a checklist at the end of the document that you may wish to print off and hang somewhere that you frequent often (i.e., on the refrigerator, or on your door). Should you have any questions, concerns, or issues as you progress through the study, please do not hesitate to reach out to us at [email protected].

Importantly, this is a double-blind study.  This means that both you and the research team do not know what study material you have.

There are two main parts to this study:

• Cognitive Challenges
• Daily Check-ins

COGNITIVE CHALLENGES

“Cognitive Challenges” are completed every 7 days. These take approximately 45 minutes to 1 hour to complete, except for the first day, which we call the Baseline Day. Baseline Day is a little different in that you will be asked to commit about 3 hours to the study in the morning.  In short, you will complete a “Cognitive Challenge”, then you will take your study material.  One hour later, you will retake the “Cognitive Challenge”.  This will allow us to see if there are any differences between our WCCE and placebo groups after just 1 dose. All other “Cognitive Challenges”, taken on Day 7, Day 14, Day 21, and Day 28, will only involve one “Cognitive Challenge”. You will receive reminders via text and email. In order to complete the “Cognitive Challenge”, you will need to download a program called Inquisit Lab to your laptop, computer, or iPad. It is important that you have access to the same laptop, desktop, or iPad on Days 7, 14, 21, and 28. You should complete all cognitive assessments on the same computer or iPad. Please do not use your smartphone for completion of the cognitive tasks as this will jeopardize the integrity of the data. To download Inquisit Lab, please visit the website https://www.millisecond.com/download/.

“Cognitive Challenges” should be completed prior to taking your study material (except on the Baseline Day when you will take it before and after you take the study material).  We ask that you wake up as you normally do, but that you do not eat or drink anything other than water prior to completing the “Cognitive Challenges”.

As a reminder, failure to miss 2 cognitive assessments in a row will lead to administrative withdrawal of your participation. You will be compensated commensurate with your participation in the study.

DAILY CHECK-INS

“Daily Check-ins” will be conducted through a smartphone app called MetricWire.  You will receive an email from the study team inviting you to the study, with links to download MetricWire from the App Store (Mac) or Google Play Store (Android). We will use MetricWire to securely send you daily text reminders and surveys. If you complete >75% of the daily surveys, you will receive $25.

When you sign-up for MetricWire, we will send you a test survey to be sure you understand how to use the app. Similarly, we will send you link to complete a mini “Cognitive Challenge” so that you become familiar with Inquisit Lab. You should not start taking the study material until you receive an email from [email protected] or a text from a member of the research team confirming your study start date.

GETTING STARTED

Do not begin taking your study material until you have received an email and/or text from the study team confirming your start date.

You must have MetricWire downloaded on your smartphone, and Inquisit Lab downloaded on your laptop, computer, or iPad.

Be sure to follow the instructions in the email or on this information guide for the Baseline Day.  On Baseline Day:

• Wake up at your normal time.
• Do not eat or drink anything but water.
• Complete the Baseline Day Cognitive Challenge 1 in Inquisit Lab.
• Take your study material with water.
• Wait 1 hour.
• Complete the Baseline Day Cognitive Challenge 2 Inquisit Lab.
• Complete the MetricWire Daily Check-in.
• Following the assessments, you can eat and drink as you would normally.
• CONGRATS!  You are done with Baseline Day!

Baseline Day is the only day that you will take the Cognitive Challenge twice.

Continue to take your study material every morning for the next 28 days.  It is important that you take the study material in the morning.  If you forget to take it in the morning, take it as soon as you remember. Please complete the daily check-ins. As a reminder, if you complete 75% or more of the daily check-ins, you will receive a $25 bonus.

72 hours within completing the study, you will receive an email with confirmation of your study participation and how much money you earned. Payment information will then be sent to administration for processing. Please allow 4-6 weeks for delivery. If you do not receive your payment in that time period, please email us at [email protected] and we will be happy to assist.